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Endocrine Abstracts

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ea0032p513 | Endocrine tumours and neoplasia | ECE2013

The embryonic transcription factor TBX1 is expressed in adult parathyroid cells and might be involved in parathyroid tumorigenesis

Verdelli Chiara , Varia Valentina , Meregalli Mirella , Terranegra Annalisa , Guarnieri Vito , Scillitani Alfredo , Passeri Elena , Vocentini Leonardo , Ferrero Stefano , Spada Anna , Corbetta Sabrina

Cancer cells and embryonic stem cells share many key biological properties and have common genetic signature: transcription factors regulating self-renewal and differentiation have been found expressed in human cancer cells. We focused our attention on TBX1, the gene involved in 22q11.2 microdeletion/DiGeorge syndrome, which is involved in heart, thymic and parathyroid cells differentiation.Real-time PCR, western blot and immunohistochemistry de...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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